Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Viralytics
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Greater than 18 years of age.
One subcutaneous melanoma metastatic deposit, 2.0 to 5.0 cm in diameter, accessible to 3mm punch biopsy and injection, may be tumour infiltrated lymph node.
Melanoma stage IV.
3mm punch biopsy of the selected tumour must be expressing ICAM-1 and DAF.
Absence of circulating antibodies to CVA21 (titre \< 1:16)
Patients must have adequate hematological, renal and hepatic function
Failed or refused standard treatment (s)
Patients are able and willing to provide signed/informed consent to participate in the study.
Fertile males and females must agree to the use of adequate form of contraception, eg. Condoms for males
Negative pregnancy test is required for female patients of child bearing potential.
You may not be if
Mucosal or ocular tumour
Presence of CNS tumour
Radiotherapy to the injection tumour site.
Prior local radiotherapy without subsequent nodule progression
Chemotherapy within 4 weeks of screening visit.
ECOG score greater than 1.
Life expectancy less than 3 months.
Pregnancy or breast feeding.
Primary or secondary immunodeficiency, including immuno-suppressive doses of corticosteroids (prednisolone greater than 7.5 mg/day, or other immuno-suppressive drugs such as cyclosporine, azothioprine, interferons, within the 4 weeks prior to screening visit.
Positive serology for HIV, Hepatitis B virus or Hepatitis C virus
Full dose anticoagulation, or a history of bleeding diathesis, or history of difficult to control bleeding in the month before screening visit.
Previous splenectomy.
Presence of uncontrolled infection.
Presence of unstable neurological disease
Any uncontrolled medical condition that in the opinion of the Investigator is likely to place the patient at unacceptable risk during the study or reduce their ability to complete the study
Participation in another study requiring administration of an investigational drug or biological agent within the last 4 weeks prior to screening visit.
Known allergy to treatment medication or excipients
Any other medical or psychological condition that would preclude participation in the study or compromise ability to give informed consent.
Clareo Health | A Safety Study of Two Intratumoural Doses of Coxsackievirus Type A21 in Melanoma Patients (PSX-X03)
