Internal Radiation Therapy With Y-90 Microspheres, External Radiation Therapy With Tomotherapy, and Fluorouracil in Treating Patients With Newly Diagnosed or Recurrent Pancreatic Cancer and Liver Metastases That Cannot Be Removed By Surgery

You may be eligible if

• DISEASE CHARACTERISTICS:
• Histologically or cytologically confirmed pancreatic cancer with liver metastases
• * Unresectable disease AND meets any of the following criteria:
• * Newly diagnosed disease
• * No prior treatment
• * Received prior treatment and progressed
• * Underwent prior pancreatectomy and progressed
• * Liver-only disease (receives selective internal radiotherapy only)
• No known CNS metastases
• No known diffuse peritoneal metastases
• PATIENT CHARACTERISTICS:
• Karnofsky performance status 80-100%
• Life expectancy \> 3 months
• WBC ≥ 1,500/mm³
• Platelet count ≥ 100,000/mm³
• Hemoglobin ≥ 9 g/dL
• Bilirubin \< 2 mg/dL (without extrahepatic biliary obstruction)
• Albumin \> 2 g/dL
• Creatinine \< 2 mg/dL
• Not pregnant
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• Prior surgery, chemotherapy, and biologic therapy allowed
• No prior external beam radiotherapy to liver or pancreatic bed