Study Of Safety, Blood Levels, And Brain Receptor Occupancy Of GSK163090 Using PET Imaging In Healthy Males

Exclusion Criteria

• •History of any cardiac disease
• •History of regular alcohol consumption averaging \>14 drinks/week
• •Current or recent gastrointestinal disease; History of psychiatric illness including any history of suicidal attempts
• •Positive for Hepatitis B and C, and HIV.
• •History of drug abuse.
• •Exposure to research and/or medical protocol involving nuclear medicine, PET or radiological investigations with significant radiation burden
• •Family history of cancer (one or more first-degree relative diagnosed before the age of 55).
• •Suffers from claustrophobia
• •History or presence of neurological or psychiatric conditions
• •Presence of a cardiac pacemaker or other implanted electronic device or metal implants