Finding studies
Finding studies
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Lead
University of California, San Francisco
With
OBJECTIVES: Primary * Determine the volume of atypical cells collected from ductal lavage in women at increased risk for breast cancer. Secondary * Determine assay techniques to analyze nipple aspirate fluid and ductal lavage fluid samples from these participants. * Analyze the nipple aspirate fluid from these participants for specific and global protein signatures. * Determine the replicability of markers in serial assays of these participants. * Determine the percentage of participants with atypia on ductal lavage in which ductal lesions can be identified using ductoscopy. OUTLINE: This is a multicenter study. Participants undergo nipple aspirate fluid and ductal lavage fluid collection. Fluid samples are analyzed using cytological analysis, immunohistochemistry, fluorescent in situ hybridization, or in situ polymerase chain reaction. Protein patterns are identified using mass spectrometry. Participants found to have atypia undergo repeat lavage at 3-6 months and 1 year. Participants with normal fluid samples undergo repeat lavage at 1 year. PROJECTED ACCRUAL: A total of 30 participants will accrued for this study within 2-3 months.
Age
18–any
Sex
FEMALE
Healthy volunteers
Not accepted