Study of Daptomycin in Subjects Undergoing Surgery for Osteomyelitis Associated With an Infected Prosthetic Caused by Staphylococci

Exclusion Criteria

• •Subject has permanent intravascular prosthetic material such as heart valves or pacemakers
• •Subject has a creatinine clearance (CLCR) \<30 mL/min as determined by the Cockcroft-Gault equation using actual body weight.
• •Subject has significant hepatic dysfunction
• •Subject has a fungal or mycobacterial PJI
• •Subject is known to be HIV-infected with CD4 count ≤ 200 cells/ mm3
• •Subject has an abnormal creatine phosphokinase (CPK) (elevated CPK level ≥ 2x ULN) at baseline as measured by central laboratory
• •Subject is currently under treatment with chemotherapeutic agents excluding chronic maintenance therapy (e.g. tamoxifen to prevent relapse of primary breast cancer)
• •Subject is pregnant, nursing, or lactating.
• •Subject is receiving or is expected to receive chronic immunosuppressive therapy during the study.