Hepatic Function in Alcoholics Following 5 Days of Acetaminophen Dosing

Exclusion Criteria

• •serum acetaminophen level greater than 20 mcg/ml
• •serum AST or ALT levels greater than 200 IU/L
• •INR greater than 1.5
• •if female, positive for beta-subunit of chorionic gonadotropin (beta-HCG)
• •clinically intoxicated, psychiatrically impaired or unable to give informed consent
• •known hypersensitivity to acetaminophen
• •history of ingesting more than four grams of APAP per day for any of the four days preceding study enrollment
• •currently enrolled in another trial or had been enrolled in another trial in the preceding three months.