Current diagnosis of Panic Disorder, or symptoms of generalized anxiety or panic attacks that could interfere with their ability to complete the trial

Symptoms of MDE better accounted for by another diagnosis

Diagnosis of panic disorder / attacks, generalised anxiety, borderline or antisocial personality disorder, dementia, anorexia nervosa / bulimia (within 6 months of screening), bipolar disorder, schizophrenia or any other psychotic disorder(s).

Started psychotherapy within 3 months prior to the Screening

Received electroconvulsive therapy or transcranial magnetic stimulation within 6 months prior to screening

Received psychoactive drugs within 4 weeks of randomization

Positive urine drug screen or positive blood alcohol

Suicidal risk or has had any previous suicide attempt, a family history of suicide attempt

Positive pregnancy test

History of seizure disorder, myocardial infarction (\< 1yr), or unstable medical condition

Failed to respond to an adequate course of pharmacotherapy of at least 2 different antidepressants

MDD POC Study GSK372475 Subjects Depressive Disease

What this study is about