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Low Dose Vasopressin in Traumatic Shock | Clinical Trials | Clareo Health

TERMINATEDEARLY_PHASE1

Low Dose Vasopressin in Traumatic Shock

Prospective, Randomized, Double-Blind, Multi-Center Trial of Low Dose Vasopressin Versus Placebo in Traumatic Shock Resuscitation

NCT00420407•The University of Texas Health Science Center at San Antonio

View on ClinicalTrials.gov

Summary

Hypothesis: We hypothesize that resuscitation regimens which minimize the total volume of resuscitation fluid, while restoring organ perfusion, will lead to lower morbidity and mortality in critically ill patients following trauma.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•To be eligible for enrollment in the study, a patient must meet all of the follow criteria at assessment:
•Patient is a male or female patient presumed to be at least 18 years of age;
•Patient has a systolic blood pressure \< 90 mmHg;
•Patient has clinical evidence of acute traumatic injury;
•Infusion of study drug must start within one hour following SBP (systolic blood pressure) \< 90 mmHg

Exclusion Criteria

•Patient is admitted to one of the study hospitals' Emergency Department greater than six hours after injury;
•Patient has received greater than 4 liters fluid since time of injury;
•Patient is enrolled in another shock trial;
•Patient is asystolic or requires CPR (cardiopulmonary resucitation) prior to randomization;
•Female patient is pregnant by report or suspicion;
•Patient has known "Do Not Resuscitate" orders or visible/identifiable method of objection to participation (e.g., exclusion bracelet);

Locations (1)

University of Texas Health Science Center at San Antonio

San Antonio, Texas, United States

Key Dates

Start Date

February 1, 2007

Primary Completion Date

April 1, 2009

Completion Date

February 1, 2011

Last Updated

June 18, 2019

Enrollment

ACTUAL participants

Conditions

InjuriesShock, Traumatic

Interventions

normal saline control

DRUG

vasopressin

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 18, 2019Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Low Dose Vasopressin in Traumatic Shock

Inclusion Criteria

Exclusion Criteria

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