Symptomatic brain metastases. Patients with signs for symptoms of brain metastases are ineligible unless brain metastases are ruled out by CT or MRI

Peripheral neuropathy ≥Grade 1 for any reason

History of thromboembolic disease or bleeding diatheses within the last 6 months

Women of child bearing potential without adequate contraception, breastfeeding, or pregnant

Serious, uncontrolled medical disorder or active infection

Uncontrolled or significant cardiac disease

Uncontrolled hypertension (150/100)

Allergy to Cremophor EL®

A Phase I Study of BMS-690514 in Combination With Paclitaxel and Carboplatin