Accelerated Partial Breast Irradiation for Early Breast Cancer

This is a TROG multicentre feasibility study of APBI using 3D CRT in selected women with node-negative breast cancer treated by breast conserving surgery with negative margins. This is a one-arm feasibility study in which the primary endpoint is the feasibility rate for APBI using 3D CRT. This is defined as the proportion of eligible patients treated without a major protocol deviation. Secondary endpoints include radiation toxicity, cosmetic outcome, quality of life, time to ipsilateral breast recurrence, disease-free survival, and overall survival. Primary objectives: To evaluate the technical feasibility and reproducibility of APBI limited to the region of the tumour bed using 3D CRT following breast conserving surgery. Secondary objectives: * To assess the acute and long term toxicity of APBI using 3D CRT. * To examine the cosmetic outcome of women with breast cancer treated by breast conserving surgery and APBI using 3D CRT. * To determine the time to ipsilateral breast recurrence, disease free survival and overall survival of women with node-negative breast cancer completely resected by breast conserving surgery followed by APBI using 3D CRT. * To assess the quality of life of women with node-negative breast cancer treated by breast conserving surgery and APBI using 3D CRT.