Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

Exclusion Criteria

• •(controls; n = 10):
• •A significant history of chronic and/or recurrent nasal symptoms (rhinorrhea, blockage,sneezing or pruritus) in response to one or more nonallergic triggers, including: perfumes or colognes, cleaning products, environmental tobacco smoke, vehicular exhaust, paint odors, changes in temperature and/or humidity.
• •(all subjects; n = 24):
• •A prior history of allergic disease (allergic rhinitis, asthma, angioedema, anaphylaxis)
• •Significant skin test reactivity to one or more substances in a panel of 24 locally relevant seasonal and perennial aeroallergens
• •Negative wheal response to positive control (histamine) on skin test panel
• •Abnormalities on a screening x-ray (Waters view) of the paranasal sinuses
• •Cigarette smoking (active, within previous 6 months or cumulative history of \>20 pack years)
• •Chronic cardiopulmonary diseases (asthma, COPD, coronary artery disease…)
• •Continuous therapy with medications having antihistaminic or autonomic primary or secondary effects (e.g., oral or topical antihistamines, tricyclic antidepressants, ipratropium bromide, albuterol, alpha- or beta-adrenergic blockers...)
• •Unable to provide meaningful tracings on screening rhinomanometry.
• •Pregnancy (or planned pregnancy within 6 months); positive urinary HCG at screening visit. Patient is a breast feeding female.
• •Upper respiratory infection (common cold or sinusitis) within 2 week of screening.
• •Patient has participated in a clinical trial involving an investigational drug within 4 weeks of visit 1.