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Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation | Clinical Trials | Clareo Health

COMPLETEDNA

Nasal Physiologic Reactivity of Nonallergic Rhinitics to Cold Air Provocation

NCT00415493•Associated Scientists to Help Minimize Allergies

Summary

This study seeks to compare patients with vasomotor rhinitis ("perennial nonallergic rhinitis," "idiopathic rhinitis") with normal controls with respect to their nasal physiologic reactivity to cold air challenge. Ten vasomotor rhinitis (VMR) patients with nasal symptoms triggered predominantly by cold air, four VMR patients with symptoms triggered predominantly by chemicals, and ten nonallergic, non-rhinitic control subjects will be studied.

Detailed Description

After initial screening and verification that subjects can cooperate with active posterior rhinomanometry, subjects will be scheduled for two 15-minute exposure sessions with either: cold-dry air, or warm-moist air. Subjects will rate symptoms (and have their nasal airway resistance measured in triplicate) prior to exposure and at 15-min. intervals post-exposure until an hour has passed.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•(cases; n = 14 total; 10 with predominantly "physical" and 4 with predominantly "irritant"triggers):
•A significant history of chronic and/or recurrent nasal symptoms (rhinorrhea, blockage,sneezing or pruritus) in response to:
•1. Changes in temperature and/or humidity predominantly ("physical triggers"; n = 10); or
•2. Two or more nonspecific irritant triggers predominantly, including: perfumes or colognes,cleaning products, environmental tobacco smoke, vehicular exhaust, paint odors, etc. ("irritant triggers";n = 4). This history shall be of at least two years' duration.

Exclusion Criteria

•(controls; n = 10):
•A significant history of chronic and/or recurrent nasal symptoms (rhinorrhea, blockage,sneezing or pruritus) in response to one or more nonallergic triggers, including: perfumes or colognes, cleaning products, environmental tobacco smoke, vehicular exhaust, paint odors, changes in temperature and/or humidity.
•(all subjects; n = 24):
•A prior history of allergic disease (allergic rhinitis, asthma, angioedema, anaphylaxis)
•Significant skin test reactivity to one or more substances in a panel of 24 locally relevant seasonal and perennial aeroallergens
•Negative wheal response to positive control (histamine) on skin test panel
•Abnormalities on a screening x-ray (Waters view) of the paranasal sinuses
•Cigarette smoking (active, within previous 6 months or cumulative history of \>20 pack years)
•Chronic cardiopulmonary diseases (asthma, COPD, coronary artery disease…)
•Continuous therapy with medications having antihistaminic or autonomic primary or secondary effects (e.g., oral or topical antihistamines, tricyclic antidepressants, ipratropium bromide, albuterol, alpha- or beta-adrenergic blockers...)
+4 more criteria

Locations (1)

ASTHMA, Inc.

Seattle, Washington, United States

Key Dates

Start Date

December 1, 2006

Primary Completion Date

October 1, 2007

Completion Date

May 1, 2008

Last Updated

March 6, 2017

Enrollment

ACTUAL participants

Conditions

Vasomotor Rhinitis

Interventions

Cold-dry air provocation

OTHER

Warm-moist air provocation

OTHER

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 6, 2017Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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