Lead Sponsor

GlaxoSmithKline

Age

18 - 64 years

Sex

ALL

Healthy Volunteers

No

•Primary diagnosis of Major depressive Disorder as defined in DSM-IV.
•Capable of giving informed consent and willing to comply with the study requirements.
•Women of childbearing potential must agree to one of a number of defined acceptable methods of birth control.

•Primary diagnosis within the past 6 months of another Axis 1 disorder such as an anxiety disorder.
•Use of medications for a psychiatric condition including herbals in the past 2-12 weeks according to medication type.
•Subjects who, in the investigator's judgement, pose a current, serious suicidal or homicidal risk or have made a suicide attempt within the past 6 months.
•Subjects who currently meet or who met within 6 months prior to screening DSM-IV criteria for substance abuse or subjects who currently meet or who met within 6 months prior to screening DSM-IV criteria for substance dependence (other than nicotine).
•Significantly abnormal blood or urine laboratory tests or electrocardiogram (ECG).