Males and females ≥ 18 yrs with atrial fibrillation (AF) and one or more of the following risk factors for stroke:

Age ≥ 75, previous stroke

transient ischemic attack (TIA) or Systemic Embolism (SE)

Symptomatic congestive heart failure or left ventricular dysfunction with left ventricular ejection fraction (LVEF) ≤ 40%

Diabetes mellitus or hypertension requiring pharmacological treatment

Apixaban for the Prevention of Stroke in Subjects With Atrial Fibrillation