Bioequivalence And Lack Of Food Effects Of 300mg Lamotrigine XR

Inclusion Criteria

• •Body weight \>50 kg (males) or \>45 kg (females) and BMI within the range 19 - 29.9 kg/m2 inclusive.
• •Healthy as determined by a responsible physician, based on a medical evaluation including history, physical examination, laboratory tests, vital signs and ECG. A subject with a clinical abnormality or laboratory parameters outside the reference range for the population being studied may be included only if the Investigator considers that the finding will not introduce additional risk factors and will not interfere with the study procedures.
• •Female subject is pregnant (positive serum human chorionic gonadotrophin (hCG) test at screening) or lactating.
• •Female subjects using hormonal contraceptive precautions including progesterone-coated IUD
• •Female subjects using hormonal replacement therapy.
• •Subjects who received lamotrigine in a previous study (subjects who received placebo will be allowed).
• •Current smokers of 10 or more cigarettes per day.