Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
National Institute of Allergy and Infectious Diseases (NIAID)
AD is a chronic inflammatory skin disease characterized by frequent viral skin infections. Recent studies have found that components in the skin of people with AD may block AMP expression. AMPs are responsible for preventing infection from viruses. The purpose of this study is to examine smallpox virus replication and AMP expression in the skin of patients with AD as well as identify other antiviral molecules involved in immune response. These findings will be compared with those of people with psoriasis or asthma, or healthy individuals. This study will consist of one study visit at which skin and blood samples will be taken.
Age
2–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
2 years of age or older
History of active or inactive AD OR eczema herpeticum, as defined by the ADVN standardized diagnostic criteria
Parent or guardian willing to provide informed consent, if applicable
Male or female of any race and ethnicity
18 years or older
History of psoriasis OR history of asthma not requiring systemic medications
Parent or guardian willing to provide informed consent, if applicable
Male or female of any race and ethnicity
You may not be if
Oral corticosteroids or any systemic immunosuppressive or immunomodulatory medication within 28 days prior to study entry
Immunotherapy within 3 months prior to study entry
History of bleeding disorder
Aspirin, oral antihistamines, oral antibiotics, oral cyclosporine, or topical medications within 7 days of screening visit including, but not restricted to, Protopic, Elidel, topical corticosteroids, and topical antibiotics
Anxiolytic agents and antidepressants within 2 days of screening visit
Diabetic requiring medication
Autoimmune or immunodeficiency
Active fungal, bacterial, or viral infections within 7 days prior to study entry
Active systemic cancer. Participants with uncomplicated nonmelanoma skin cancer are not excluded.
Theophylline or leukotriene antagonists within 24 hours of screening visit
Received any vaccination within 30 days prior to study entry
Known lidocaine allergy
Previously vaccinated for smallpox
Pregnant or breastfeeding
Clareo Health | Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus
