Role of Antimicrobial Peptides in Host Defense Against Vaccinia Virus

Exclusion Criteria

• •Oral corticosteroids or any systemic immunosuppressive or immunomodulatory medication within 28 days prior to study entry
• •Immunotherapy within 3 months prior to study entry
• •History of bleeding disorder
• •Aspirin, oral antihistamines, oral antibiotics, oral cyclosporine, or topical medications within 7 days of screening visit including, but not restricted to, Protopic, Elidel, topical corticosteroids, and topical antibiotics
• •Anxiolytic agents and antidepressants within 2 days of screening visit
• •Diabetic requiring medication
• •Autoimmune or immunodeficiency
• •Active fungal, bacterial, or viral infections within 7 days prior to study entry
• •Active systemic cancer. Participants with uncomplicated nonmelanoma skin cancer are not excluded.
• •Theophylline or leukotriene antagonists within 24 hours of screening visit
• •Received any vaccination within 30 days prior to study entry
• •Known lidocaine allergy
• •Previously vaccinated for smallpox
• •Pregnant or breastfeeding