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Keep this study
Lead
Lux Biosciences, Inc.
Age
13–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
A documented history of non-infectious intermediate, anterior and intermediate, posterior or panuveitis.
Minimum prescribed therapy upon enrollment is one or more of the following:
* systemic prednisone or equivalent averaging ≥ 10 mg/day
* at least 2 periocular/intravitreal corticosteroid administrations for control of inflammatory disease within the previous 8 months (but not within 6 weeks of randomization).
* at least one, but not more than 2 immunosuppressive drugs from among the following compounds: cyclosporine, tacrolimus, azathioprine, mycophenolate mofetil, methotrexate
Subjects with clinically quiescent uveitis in both eyes at enrollment and who have been on a stable treatment regimen for a minimum of 6 weeks
Best-corrected distance visual acuity in the worst involved eye of 20/400 or better (ETDRS logMAR \<1.34)
Subjects not planning to undergo elective ocular surgery during the study
You may not be if
Evidence of active, uncontrolled non-infectious uveitis
Periocular administration of corticosteroids within the previous 6 weeks.
Uveitis of infectious etiology
Uncontrolled glaucoma
Clinically suspected or confirmed central nervous system or ocular lymphoma
History or diagnosis of Behçet's disease
Primary diagnosis of anterior uveitis
Clareo Health | A Study of LX211 in Clinically Quiescent Non-infectious Intermediate, Anterior and Intermediate, Posterior or Pan-Uveitis