High-Dose Oral Ziprasidone Versus Conventional Dosing in Participants With Residual Schizophrenia Symptoms

Exclusion Criteria

• •Past or current intolerance of ziprasidone side effects
• •Presence of significant cardiac disease, including uncompensated congestive heart failure, myocardial infarction within the past 6 months or known history of congenital long QT interval syndrome
• •Corrected QT interval (QTc) greater than or equal to 500 milliseconds (msec)
• •Serum potassium and magnesium concentrations outside of normal limits.
• •Currently taking any medications which may affect cardiac conduction
• •Presence of any unstable or untreated medical disorder
• •Any history of seizures or seizure disorder other than febrile seizures of childhood
• •History of positive hepatitis B surface antigen
• •Human immunodeficiency virus (HIV) positive or has diagnosis of acquired immune deficiency syndrome (AIDS)
• •Any abnormal laboratory test that is judged to be clinically significant by the investigator
• •History of neuroleptic malignant syndrome (NMS), hypersensitivity or allergic response to antipsychotic therapy, including ziprasidone
• •History of clozapine treatment for refractory psychotic symptoms
• •Alcohol or substance dependence within the past 12 months or abuse within the past 3 months. Any subject with positive urine toxicology or alcohol use that is considered abnormal at baseline.
• •Clinically significant suicidal or homicidal behavior or attempts within past 6 months
• •Any subject judged by the investigator to present a danger to self or others.
• •Women of childbearing potential who are not using adequate contraception (oral contraceptives, barrier methods or who are clearly abstinent)
• •Pregnancy or breast-feeding
• •Any subject who is judged by the investigator to be unable or unlikely to comply with all study requirements, including adherence with prescribed medication regimen