Any patient, regardless of gender or ethnicity, who was:

1. 18 years or older

2. admitted to one of the two controlled access alcohol detoxification centers with a positive BAL at the time of admittance

3. signed a written informed consent form.

Patients were excluded from the study at baseline if any of the following were present:

1. serum acetaminophen level greater than 20 mcg/ml

2. serum AST or ALT levels greater than 200 IU/L

3. INR greater than 1.5

4. if female, positive for beta-subunit of chorionic gonadotropin

5. clinically intoxicated, psychiatrically impaired or unable to give informed consent

6. known hypersensitivity to acetaminophen

7. history of ingesting more than four grams of APAP per day for any of the four days preceding study enrollment

8. currently enrolled in another trial or had been enrolled in another trial in the preceding three months.

Hepatic Function During and Following Three Days of Acetaminophen Dosing in Alcoholics