Lead Sponsor

Ironwood Pharmaceuticals, Inc.

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•Patient is 18 years of age or older
•Patient meets colonoscopy requirements according to the American Gastroenterological Association
•Patient meets criteria for chronic constipation including weekly bowel movement frequency requirements and reports one or more symptoms of constipation according to protocol requirements
•Patient has successfully completed study requirements with no clinically-significant findings: physical exam, ECG, clinical laboratory tests
•Patient is fluent in English

•Patient reports loose or watery stools
•Patient meets criteria for IBS including protocol-defined abdominal discomfort or pain
•Patient may not take prohibited medications per protocol
•Medical diagnoses, medical conditions, or family history that would not make the patient a good candidate for the study or limit the patient's ability to complete the clinical study