Study of PEG-Intron for Plexiform Neurofibromas

Exclusion Criteria

• •Clinically significant unrelated systemic illness.
• •Received an investigational agent within the past 30 days.
• •Evidence of active visual pathway glioma
• •History of malignant peripheral nerve sheath tumor or ther cancer other than surgically cured non-melanoma skin cancer or cervical carcinoma in situ
• •Ongoing radiation therapy, chemotherapy, hormonal therapy directed at the tumor, or immunotherapy.
• •Inability to return for follow-up visits or obtain follow-up studies
• •Severe cardiovascular disease
• •Pre-existing sever psychiatric condition or history of psychiatric disorder requiring hospitalization or a history of suicidal ideation or attempt.
• •Thyroid dysfunction not responsive to therapy.
• •Uncontrolled diabetes mellitus
• •History of seropositivity for HIV
• •Subjects who are pregnant, lactating, or of reproductive potential and not practicing an effective means of contraception.
• •Any medical condition requiring chronic systemic corticosteroids.
• •Subjects who are known to be actively abusing alcohol or drugs.