Radiation Therapy After Prostatectomy in Treating Patients With Stage III Prostate Cancer

You may be eligible if

• PROTOCOL ENTRY CRITERIA:
• -Disease Characteristics--
• Pathologically documented Stage C (T3 N0 M0) adenocarcinoma of the prostate following radical prostatectomy and pelvic lymphadenectomy for clinical Stage A/B disease
• Ineligible for SWOG protocols of higher priority
• At least 1 of the following on pathologic examination:
• * Presence of cancer in the seminal vesicles
• * Evidence of cancer at the inked surgical margin of the prostate
• * Extension of tumor beyond the prostatic capsule
• Negative preoperative metastatic survey within 6 months prior to registration, including the following:
• * Normal bone scan
• * No palpable evidence of extraprostatic tumor extension
• Bilateral lymph node dissection histologically negative for cancer
• Nodal sampling not required with the following stage/biopsy specimen Gleason score/preoperative PSA:
• * Stage T1a/2-6/\<10 ng/ml
• * Stage T1b-c/2-5/\<10 ng/ml
• * Stage T2a/2-6/\<10 ng/ml
• * Stage T2b/2-6/\<6 ng/ml
• * Stage T2c/2-6/\<4 ng/ml
• Free from the following postoperative complications:
• * Total urinary incontinence
• * Intraoperative rectal injury
• * persistent urinary extravasation
• * Pelvic infection
• Concurrent registration on protocol SWOG-9205 (serum repository protocol) optional
• Concurrent registration on protocol SWOG-8994 (quality-of-life study) required of English-speaking and Spanish-speaking patients enrolled by SWOG
• -Patient Characteristics--
• Age: Any age
• Performance status: SWOG 0-2
• Life expectancy: At least 2 years
• Hematopoietic:
• * WBC at least institutional LLN
• * Platelets at least institutional LLN
• Hepatic: SGOT no more than 2 x ULN
• Other: No second malignancy within 5 years except adequately treated nonmelanomatous skin cancer
• -Prior Concurrent Therapy--
• Chemotherapy: No prior chemotherapy for prostate cancer
• Endocrine therapy: No more than 3 months of hormonal therapy prior to prostatectomy allowed
• Radiotherapy: No prior radiotherapy for prostate cancer
• Surgery: Radical prostatectomy and pelvic lymphadenectomy within 16 weeks prior to registration required