Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Michael E. DeBakey VA Medical Center
With
Solvay Pharmaceuticals
Volunteers will be treated with a prescription testosterone gel applied to the shoulder or other body area each day. This treatment will continue for 6 months. Subjects will undergo a PET scan at the beginning of the study and after approximately 2 months of treatment. Subjects will undergo some cognitive testing throughout the study.
Age
55–any
Sex
MALE
Healthy volunteers
Not accepted
You may be eligible if
Alzheimer's disease diagnosis, based on Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-V)
Stable on concomitant medications for 1 month prior to starting study
You may not be if
history of prostate cancer
history of breast cancer
gonadal endocrine disorders
current major psychiatric illness (excluding depression)
significant uncontrolled systemic illness
recent myocardial infarction (within 6 months)
renal or hepatic disease, sleep apnea
history of alcoholism or substance abuse within the past year
history of head injury with loss of consciousness greater than 1 hour
testosterone or other androgen treatment within past 3 months
history of taking other drugs that might interfere with the results of the study (ie, spironolactone, cimetidine, antiandrogens, estrogens, p450 enzyme inducers, barbiturates)
symptomatic BPH: prostatic symptoms, prostatic masses or induration on rectal examination
prostate specific antigen (PSA) \>4.0 mg/mL
hemoglobin \> 17 mg/dL
generalized skin disease that could affect the absorption of testosterone gel (ie, psoriasis).
potentially agitated or uncooperative for procedures
