Pazopanib (VOTRIENT) Plus Paclitaxel (TAXOL), Pazopanib Plus Paclitaxel (TAXOL) Plus Carboplatin (PARAPLATIN), and Pazopanib Plus Paclitaxel (TAXOL) Plus Lapatinib (TYKERB)

Exclusion Criteria

• •No more than 3 prior lines of cytotoxic chemotherapy for metastatic disease are allowed.
• •No major surgery, nor cytotoxic chemotherapy, investigational agents, or radiotherapy within the last 28 days and subject must have recovered fully from whatever their last treatment was at the time of enrollment.
• •Cannot have poorly controlled hypertension.
• •Cannot have corrected QT (QTc) prolongation
• •Cannot have Class III or IV heart failure as defined by the New York Heart Association functional classification system.
• •Cannot have arterial or venous thrombi (including cerebrovascular accident), myocardial infarction, admission for unstable angina, cardiac angioplasty, or stenting within the last 3 months.
• •Cannot use of therapeutic warfarin.
• •Cannot have history of bleeding (hemoptysis, hematuria, GI blood loss, epistaxis, or others with greater than Grade 1 according to CTC Criteria) within six weeks prior to beginning therapy or any clinical indications of current active bleeding or bleeding diathesis.
• •Cannot have history or clinical evidence of CNS metastases or leptomeningeal carcinomatosis, except for individuals who have previously treated CNS metastases, are asymptomatic, and have had no requirement for steroids or anti-seizure medication for 2 months prior to beginning study treatment.
• •Cannot have any serious and/or unstable pre-existing medical, psychiatric, or other condition (including laboratory abnormalities) that could interfere with patient safety or obtaining consent.
• •Cannot have history of malabsorption syndrome, disease significantly affecting gastrointestinal function or major resection of the stomach or small bowel that could affect absorption, distribution, metabolism or excretion of pazopanib, paclitaxel, or carboplatin. Has any unresolved bowel obstruction or diarrhea. Has clinically significant gastrointestinal abnormalities that may increase the risk for GI bleeding including, but not limited to:
• •* active peptic ulcer disease,
• •* known intraluminal metastatic lesion(s) with suspected bleeding,
• •* inflammatory bowel disease including ulcerative colitis, or other GI conditions with increased risk of perforation,
• •* history of abdominal fistula, GI perforation, or intra-abdominal abscess within 28 days prior to beginning study treatment.
• •Subject must not have psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol.
• •Subject must not take any specifically prohibited medication specified in the protocol during the study or requires any of these medications during treatment with pazopanib.
• •Subject must not have clinical history, current alcohol or illicit drug use which, in the judgment of the Investigator, would interfere with the patient's ability to comply with the dosing schedule and protocol-specified evaluations.
• •Subject must not be allergic to either TAXOL or PARAPLATIN, or any other taxane or platinum containing compound.
• •Subject must not have a current diagnosis of cervical cancer.
• •Subject must not have known endobronchial metastasis or involvement of large pulmonary vessel(s) by tumor.