Physician diagnosis of migraine; history of triptan or ergot use; history of headache prophylaxis use

Pregnant and/or nursing mother

History of cardiovascular disease.

Uncontrolled hypertension.

Basilar or Hemiplegic migraine

History of stroke or transient ischemic attacks (TIA).

History of epilepsy or treated with anti-epileptics within the past 5 years.

Impaired hepatic or renal function.

History of gastrointestinal bleeding or ulceration.

Allergy or hypersensitivity to Aspirin or any other NSAID.

Allergy or hypersensitivity to triptans.

Participated in an investigational drug trial in the previous 4 weeks.

TREXIMET (Formerly Known as TREXIMA) for the Acute Treatment of Probable Migraine (ICHD-II 1.6.1)