Patient is at immediate risk for suicidal behavior

Patient is with a unstable medical condition

Patient with psychotic features, catatonic features, seasonal pattern or postpartum onset

Patient has taken concomitant treatment that may interfere with valid collection or interpretation of study data

Patient has been treated with non-pharmacologic therapy intended to treat depression in the past 6 months

Patient has been treated with paroxetine (Paxil) within the previous 6 months

Patient is pregnant or breastfeeding, or likely to become pregnant during the course of the study

Efficacy and Safety of SR58611A in Patients With Major Depressive Disorder (SIRIUS)