Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
The Alfred
With
Roche Pharma AG
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
males and females over 18 years of age
Documented CHF (NYHA class II-IV symptoms)
Airflow obstruction defined as patients with symptomatic obstructive respiratory disease as manifest by any of the following Symptoms of wheeze, primarily attributed to airflow obstruction Requirement for intermittent or regular bronchodilator therapy FEV1 less than 70% predicted pre-salbutamol
Confirmed written informed consent.
Clinically indicated to receive β-blockade.
No evidence of heart block on ECG.
Patients will be in one of the following categories:
Currently on carvedilol Currently on Toprol-XL or Metoprolol tartrate Currently on bisoprolol Clinically indicated to receive β adrenoceptor blockade but not currently prescribed a β-blocker.
You may not be if
Women lactating, pregnant or of childbearing potential not using a reliable contraceptive method.
Patients who had received an investigational new drug within the last 4 weeks.
Patients with a history of a psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study.
Laboratory parameters:
Creatinine \>0.30 mmol/l Liver function tests 3x ULN
Recent (\<12 months) myocarditis
Clareo Health | A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure
