Mifepristone Versus Laminaria for Cervical Ripening in Midtrimester Induction

Randomized Controlled Trial of Mifepristone Versus Laminaria for Cervical Ripening In Midtrimester Induction

NCT00383032•Dartmouth-Hitchcock Medical Center

Summary

Data from other countries have suggested that oral mifepristone used as a cervical ripening agent may decrease induction to delivery time in midtrimester inductions. To our knowledge, there are no trials comparing mifepristone to laminaria in a standard clinical setting with standardized misoprostol induction protocol to examine the issue of induction to delivery time. We hypothesize that mifepristone will work at least as well as laminaria for midtrimester cervical ripening prior to induction of labor with misoprostol.

Eligibility

Age

16 - No limit years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•pregnant women with fetal anomalies, aneuploidy, or demise at 15-22 weeks gestation
•age greater than 16
•able to speak English

Exclusion Criteria

•prior uterine scar or
•allergy or history of bad reaction to any of the study drugs or
•history of chronic adrenal failure or
•porphyria or
•concurrent long-term corticosteroid treatment

Locations (1)

Dartmouth-Hitchcock Medical Center

Lebanon, New Hampshire, United States

Key Dates

Start Date

January 1, 2004

Completion Date

June 1, 2006

Last Updated

October 24, 2023

Enrollment

Estimated participants

Conditions

Abortion, Induced

Interventions

mifepristone

DRUG

Postoperative Pain After Medical Abortion Under Local Anesthesia : Comparison of Several Analgesic Regimen

NCT00188071

Abortion, Induced

View study

TERMINATEDNA

Pilot Study of the Addition of Osmotic Dilators to Preparation Prior to Labor Induction Abortion

NCT00855842

Abortion, Induced

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 24, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions