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Epileptic disease is characterised by enhanced brain excitability. Low frequency repetitive transcranial magnetic stimulation (rTMS) can be an effective treatment for refractory frontal epilepsy. Thought, physiological mechanisms of its effectivity are still unknown. It is yet possible to evaluate cortical excitability and inhibition with TMS-coupled electromyography before and after rTMS sessions ; this could provide clues for basic mechanisms of rTMS effects on the epileptic brain. We assume that rTMS decrease brain excitability by improving brain inhibition. Such an information could help for treating patients with both pharmacological and non-pharmacological methods.
Age
12 - No limit years
Sex
ALL
Healthy Volunteers
No
Département de Neurologie - Hôpital Civil
Strasbourg, France
Institut de Physique Biologique
Strasbourg, France
Start Date
May 1, 2006
Primary Completion Date
September 1, 2009
Completion Date
August 1, 2011
Last Updated
October 1, 2025
15
ESTIMATED participants
cortical magnetic stimulation provided by an eight-shaped coïl placed upon the skull.
DEVICE
Lead Sponsor
University Hospital, Strasbourg, France
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