Lead Sponsor

Bristol-Myers Squibb

Age

18 - 70 years

Sex

ALL

Healthy Volunteers

Yes

•Male and females ≥18 years old
•Women must be of non-childbearing potential
•Adequate hematologic and renal function
•BMI 18-35 kg/m2
•Subjects must have stable liver impairment diagnosed with standard classification - Child Pugh

•Inability to swallow or absorb oral medication
•Uncontrolled medical disorder or infection
•Use of CYP3A4 inhibitors/inducers or drugs with risk of Torsades de Pointes
•Uncontrolled or Significant cardiovascular disease
•Any significant bleeding disorder
•Female subjects of childbearing potential
•Male subjects unwilling to use an effective method of contraception throughout the conduct of the study and for 2 months thereafter