Phase II Trial of Aprepitant & Palonosetron for CINV Prevention w FOLFOX

You may be eligible if

• DISEASE CHARACTERISTICS:
• Diagnosis of colorectal cancer
• Metastatic disease
• Scheduled to receive 1 of the following chemotherapy regimens\*:
• * FOLFOX 4 (oxaliplatin, fluorouracil, leucovorin calcium)
• * FOLFOX 6
• * FOLFOX 7
• * FOLFIRI (irinotecan hydrochloride, fluorouracil, leucovorin calcium) NOTE: \*Regimens may also include cetuximab or bevacizumab
• No emesis and no requirement for antiemetic agents within 48 hours prior to beginning chemotherapy
• * Single-agent benzodiazepines as a hypnotic allowed
• No chronic nausea
• PATIENT CHARACTERISTICS:
• Eastern Cooperative Oncology Group (ECOG) performance status 0-2
• Life expectancy \> 4 months
• White Blood Cell(WBC)count \> 3,000/mm\^³
• Absolute neutrophil count (ANC) \> 1,500/mm\^³
• Platelet count \> 100,000/mm\^³
• Bilirubin ≤ 2.5 times upper limit of normal (ULN) (\< 5 times ULN if liver metastases present)
• Creatinine ≤ 1.5 times ULN
• Aspartate aminotransferase(AST) or Alanine aminotransferase (ALT) ≤ 2.5 times ULN (\< 5 times ULN if liver metastases present)
• Able to swallow tablets and capsules
• No known sensitivity to aprepitant, palonosetron hydrochloride, or dexamethasone
• Not pregnant or nursing
• Negative pregnancy test
• No history of consuming ≥ 5 alcoholic drinks/day within the past year
• No concurrent illness requiring systemic corticosteroids other than planned dexamethasone during study treatment
• No clinical signs of active systemic infection involving the gastrointestinal tract
• No active bowel obstruction
• PRIOR CONCURRENT THERAPY:
• See Disease Characteristics
• No prior chemotherapy \> Hesketh level 3
• * Prior fluorouracil with or without leucovorin calcium or capecitabine allowed
• At least 30 days since prior investigational drugs
• At least 14 days since prior neurokinin-1 antagonists
• Concurrent hydrocortisone at physiologic replacement doses (≤ 30 mg/day) allowed
• No concurrent chronic antiemetic agents
• Concurrent hypnotics allowed
• Concurrent rescue antiemetics allowed