Study Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses in Healthy

You may be eligible if

• Healthy men or women, aged 18 to 40 years and subjects with osteoarthritis of the knee, aged 40 to 75 years.
• Women must be of non-childbearing potential, defined as surgically sterile with documentation of ultrasound.
• Must be nonsmoker or smoke less than 10 cigarettes per day.