Lead Sponsor

Evotec Neurosciences GmbH

Age

21 - 64 years

Sex

ALL

Healthy Volunteers

No

•must have a diagnosis of primary insomnia
•over the last three months, must have a normal bedtime of between 9 pm and 1 am and a time in bed of at least 7 hours
•must be able to attend the Sleep Center for two consecutive nights on four occasions over a two month period
•must be willing and able to complete a sleep diary and questionnaires

•must not have a clinically significant or unstable medical condition that may interfere with sleep
•must not have a major psychiatric disorder (other than insomnia) such as depression, schizophrenia, bipolar disorder
•must not be currently using any medication know to affect sleep e.g. hypnotics, anxiolytics,antidepressants, antihistamines, anticonvulsants
•must not intentionally nap 3 (or more) times per week
•must not smoke more than 10 cigarettes per day and /or be able not to smoke without distress or discomfort for the duration of visits to the sleep laboratory ( i.e. approximately 12 hours)

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