COPD exacerbation requiring steroid and/or antibiotics in the last month

Taking oral or inhaled steroids for more than 14 days in the last 6 months

Unable to withhold salbutamol/albuterol for a 6 hour period

History of alcohol, substance or drug abuse within the last year.

Other significant medical condition e.g. diabetes

Cancer that has not been in complete remission for at least 5 years

As a result of the medical interview, physical examination or screening investigations, that the doctor considers the subject unfit for the study.

Prednisolone Novel Endpoint Study in Patients With Chronic Obstructive Pulmonary Disease (COPD)