Metabolic Effects of Thiazolidinediones in Chronic Kidney Disease

Exclusion Criteria

• •1. Patients with prior documented diagnosis of diabetes mellitus.
• •2. Patients with fasting blood glucose \> 110mg/dL.
• •3. Prisoners, patients will significant mental illness, pregnant women, and other vulnerable populations.
• •4. Patients with active hepatic disease and/or ALT \> 2.5 times upper limit of normal.
• •5. Patients with history of congestive heart failure and NYHA Class III-IV symptoms at any time.
• •6. Patients for whom living donor renal transplantation is already scheduled or in the process of being evaluated, as these patients will be unlikely to complete study protocols before transplantation.
• •7. Patients with severe co-morbid conditions (eg, symptomatic hepatic cirrhosis, metastatic cancer, HIV infection with AIDS).
• •8. Patient with active inflammatory process (eg., SLE, rheumatoid arthritis, gout) for which they are currently receiving immune modulating medications.
• •9. Patients who are on corticosteroid therapy.
• •10. Patients who do not consent to participate in the study.