Study Comparing On-Demand Treatment With Two Prophylaxis Regimens Of BeneFIX In Patients With Severe Hemophilia B

Exclusion Criteria

• •Subjects currently utilizing FIX primary prophylaxis.
• •Subjects with HIV+ who have a CD4 count less than 200
• •Subjects with hepatic or renal impairment.
• •Prothrombin time or International Normalized Ration more than 1.5 times the upper limit of normal.
• •Major surgery or an orthopedic surgical procedure within the past 3 months or is planned within the duration of participation in this study.
• •Past history of, or current FIX inhibitor.
• •Hypersensitivity to any FIX product or hamster protein.
• •Exposure to any investigational drug, except for rFIX-R, or device within 30 days of providing consent/assent (as appropriate) for this study.
• •Bleeding disorders other than hemophilia B.
• •Concurrent inflammatory disease that in the investigator's judgment could confound the study results.