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Keep this study
Lead
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
The pilot investigation will examine the hypothesis that human infertility may be caused by mutations in the human MATER gene. We will determine the prevalence of these mutations in a select group of women who have a clinical infertility history consistent with a possible defect in a maternal effect gene. After obtaining informed consent and DNA from 100 women, relevant mutations in the MATER gene will be searched for by single strand conformation polymorphism analysis.
Age
Any age
Sex
FEMALE
Healthy volunteers
Not accepted
You may be eligible if
Women to be included in this study will have a clinical infertility history that would be consistent with a possible defect in a maternal effect gene.
This includes women who meet the following criteria:
1. a clinical diagnosis of infertility,
2. never been pregnant, and
3. undergone treatment by in vitro fertilization and had at least 8 fertilized eggs as part of at least one in vitro fertilization cycle that failed to lead to a clinical pregnancy.
Women who have subsequently achieved a pregnancy by egg donation will be included.
