AVANDAMET Versus Metformin And Sulphonylurea In People With Poorly Controlled Type 2 Diabetes

Exclusion Criteria

• •Use of any other oral antidiabetic drug other than metformin within 12 weeks prior to screening.
• •Subjects with clinically significant ongoing oedema requiring pharmacological treatment or with a history of oedema requiring pharmacological treatment.
• •Subjects with a history of severe hypoglycaemia.
• •Renal disease or renal dysfunction.
• •Presence of clinically significant hepatic disease.
• •Presence of unstable or severe angina or known NYHA grade I-IV congestive heart failure.
• •Subjects who have had a previous myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass graft or cerebrovascular accident within 3 months prior to screening.