Prostate Cancer Screening and Dietary Heterocyclic Amines in African American Men

OBJECTIVES: * Estimate dietary heterocyclic amine (HA) exposure in African American men who use HA-forming meats and cooking methods. * Correlate dietary HA exposure with prostate-specific antigen and digital rectal exam screening results (i.e., higher HA exposure with increased abnormality in prostate cancer screening results) in these participants. OUTLINE: This is a prospective study. Participants complete a routine medical questionnaire and undergo a detailed dietary interview that focuses on meat consumption, cooking preferences, and other factors that may be associated with prostate cancer risk. Participants then undergo a digital rectal exam (DRE) and blood collection for prostate-specific antigen (PSA) testing (total PSA and % free PSA). Results of PSA testing and DRE, including follow-up instructions (if needed), are sent to the participant 3-4 weeks later. Blood samples are also examined by phenotypic assays for UV-damage induced nucleotide excision-repair capacity. PROJECTED ACCRUAL: A total of 800 participants will be accrued for this study.