Research Study Using Recombinant Human Insulin-Like Growth Factor-1/Recombinant Human Insulin-Like Growth Factor Binding Protein-3 for Children With Noonan Syndrome

Inclusion Criteria

• •1. A diagnosis of Noonan syndrome
• •2. Height less than the 3rd percentile for age and sex (height SDS \< -1.88)
• •3. Basal IGF-I less than the mean for age and sex (IGF-I SDS \< 0)
• •4. Chronological age greater than 2 years
• •5. Bone age ≤ 11 years for boys, and ≤ 10 years for girls
• •6. Pre-pubertal
• •7. Documented pre-treatment height velocity less than the mean for age and sex