Safety and Effectiveness of PRX-08066 in Patients With Pulmonary Hypertension and Chronic Obstructive Pulmonary Disease

Exclusion Criteria

• •1. Left ventricular ejection fraction \<30%.
• •2. Heart attack or stroke within the last 6 months.
• •3. History of lung resection surgery.
• •4. Use of supplemental oxygen \>20 hours/day.
• •5. Blood donation or significant blood loss within the last 56 days.
• •6. Plasma donation within the last 14 days.
• •7. Use of any drugs for another research study within the last 30 days.
• •8. Use of vasodilators, long acting nitrates, prostacyclin analogs, endothelin antagonists, or phosphodiesterase inhibitor drugs within the last 14 days.
• •9. Positive blood screen Hepatitis B surface antigen (HBsAg) or Hepatitis C Antibody.
• •10. Major surgery within the last 28 days.
• •11. Any other medical condition that may jeopardize the safety of the subject, the validity of the study results, or interfere with the completion of the study according to the protocol.