Loading clinical trials...

Genetic Analysis of Hereditary Non-Syndromic Oral Clefts | Clinical Trials | Clareo Health

COMPLETED

Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

NCT00340626•National Human Genome Research Institute (NHGRI)

Summary

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Detailed Description

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. Healthy Syrian individuals with no family history of oral clefts will also be enrolled as a comparison group. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease. All families are enrolled into the study by our Syrian collaborators (under Ethics Board approval from the IBN AL-NAFEES Hospital) and only coded phenotype data and coded biospecimens are ever received at the NIH.

Eligibility

Age

All ages

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:
•1. A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
•2. The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.
•3. The occurrence of oral clefts in 2 or more cousins (up to second cousins)
•The subject population is comprised of probands and their families previously examined at the IBN-AL NAFEES Hospital or at other hospitals and clinics in the Syrian Arab Republic as well
•as healthy controls from the same population. Consent documents are in Arabic language for non-English-speaking subjects

Exclusion Criteria

•Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

Locations (1)

IBN Al Nafees Hospital

Damascus, Syria

Key Dates

Start Date

August 31, 1997

Primary Completion Date

March 12, 2020

Completion Date

March 12, 2020

Last Updated

March 13, 2020

Enrollment

690

ACTUAL participants

Conditions

Hereditary Oral Clefts

Genetic Analysis of Neural Tube and Orofacial Cleft Defects in the Irish Population

NCT00341068

Neural Tube Defects (NTDs)Facial Cleft Defect+1 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 13, 2020Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions