History of and signs/symptoms of uncontrolled brain metastases or edema.
Previous treatment with chemotherapy or any biological anti-cancer drug (prior adjuvant therapy with interferon-alpha is permitted as long as treatment was completed at least six months prior to study entry.)
Radiotherapy: Radiation therapy within 4 weeks prior to entering the study.
Receipt of any investigational drug for treatment of metastatic melanoma prior to this trial.
