Thyroid Dysfunction in Women With Newly Diagnosed Breast Cancer Compared to Healthy Volunteers

Inclusion Criteria

• •CASE SELECTION:
• •Women between the ages of 25 and 75
• •Diagnosed with primary and operable Stage I - IIIB breast cancer
• •Scheduled to receive neoadjuvant or adjuvant Adriamycin and Cytoxan (AC) plus a taxane (taxane may be given with AC or follow AC)
• •No chemotherapy prior to baseline sample collection
• •No prior history of other cancers (except non-melanoma skin cancer)
• •Preoperative radiation therapy is permitted
• •No diagnosis of hypothyroidism or hyperthyroidism.
• •Cannot be a blood relative of the case. They can be friends, neighbors, women from social activities, local business, doctors' offices, etc.
• •Must live near or in the town of the case
• •Women between the ages of 20 and 80 (age-matched to cases +/- 5 years)
• •No prior history of cancer (except non-melanoma skin cancer)
• •Women ages 40 and older should have had a mammogram within 2 years of study entry, showing no evidence of breast cancer.
• •The friend control may bring their mammogram report or send a release and have records faxed to the enrolling center.
• •Women under the age of 40 should have had a clinical breast examination within 2 years of study entry, showing no need for diagnostic mammography. If a mammogram was required, it should show no evidence of breast cancer.
• •The friend control may bring their mammogram / breast exam report or send a release and have records faxed to the enrolling center.