Study to Evaluate the Clinical Benefit Response in Cancer Patients With Advanced Disease With AMT2003 Versus Placebo

Exclusion Criteria

• •Known secondary neoplasia or central nervous system (CNS) metastases, acute or chronic leukemia, lymphoma or multiple myeloma
• •Body weight below 45 kg
• •Female patients who are pregnant or breast feeding or adults of reproductive potential not employing effective birth control methods
• •Concurrent severe or uncontrolled medical disease
• •Acute or chronic liver disease
• •Confirmed diagnosis of HIV
• •Insulin dependent diabetes mellitus/abnormal glucose tolerance test (GTT)/latent diabetes mellitus type I or II
• •Chemotherapy or radiotherapy less than 4 weeks prior to entry
• •Surgery less than 2 weeks prior to entry (or not recovered from effects of surgery)
• •Participation in a clinical trial less than 30 days prior to entry into this study