Combined Pharmaco/Behavior Therapy in Adolescent Smokers

Exclusion Criteria

• •1. Active substance abuse/dependence (other than nicotine) within 2 weeks prior to participating in the study
• •2. Lifetime bipolar affective disorder (BPAD), psychosis, eating disorders. Bupropion may have adverse consequence on participants with these psychiatric diagnoses.
• •3. Current major depressive disorders. Since bupropion is also an antidepressant, this criteria is to minimize the confound of depressive disorder during the study. History of depressive disorders and current attention deficit hyperactivity disorder (ADHD) will not be an exclusion. We will use permuted block randomization procedure to balance the groups for ADHD.
• •4. Pregnancy or lactation. The safety of bupropion in pregnancy and during lactation is not well studied.
• •5. History of seizure disorder or predisposition to seizures (e.g., history of significant head trauma, currently taking medications that lower seizure threshold), since bupropion can lower seizure threshold.
• •6. History of severe renal, hepatic, neurological, or chronic pulmonary disease. This criterion was chosen due to the hepatic metabolism of bupropion.
• •7. Unstable medical problems
• •8. Allergy to bupropion
• •9. Current treatment with any other medication containing bupropion
• •10. Current treatment with any monoamine oxidase (MAO) inhibitors currently or within 2 weeks of starting the study since there may be serious and severe medical interactions between MAO inhibitors and bupropion SR.
• •11. Current treatment with nicotine replacement therapy (NRT)
• •12. History of intolerance or non-response to bupropion SR.
• •13. Current (past month) suicide ideation
• •14. Suicide attempt (past year)