Acamprosate in Alcoholics With Comorbid Anxiety or Depression

Inclusion Criteria

• •1. Adults ages 18-60
• •2. Meet DSM-IV criteria for current (past 90 days) alcohol dependence
• •3. Must identify alcohol as the primary substance of abuse
• •4. Meet DSM-IV criteria for a current major depressive episode, GAD and/or social anxiety disorder
• •5. Have a stable psychiatric condition, as evidenced by a baseline CGI change score of 4 or below between the time of initial screening and the baseline visit, and if receiving psychotropic medication, must have a stable dose of medication for at least one month prior to baseline.
• •6. Must have a negative urine drug screen at the baseline visit; UDS may be repeated no more that twice to obtain an negative UDS
• •7. May be receiving medication treatment for anxiety/mood disorder as long as the dosage has been stable for 4 weeks prior to randomization.
• •8. May be engaged in psychosocial treatment for alcohol dependence or for mood/anxiety disorders.
• •9. Must abstain from alcohol for at least 3 consecutive days but no more than 21 days prior to medication initiation
• •10. Subjects must be able to adequately provide informed consent and function at an intellectual level sufficient to allow the accurate completion of all assessment instruments
• •11. Subjects must consent to random assignment, be willing to commit to medication treatment and follow-up assessments
• •12. CIWA-Ar scale is 8 or less at the baseline visit