Aripiprazole Augmentation for Clozapine-Treated Patients With Refractory Schizophrenia

Inclusion Criteria

• •Male or female patients, 18-65 years of age.
• •Patients must have a diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV).
• •Female patients of menarche must be using a medically accepted means of contraception (e.g. oral contraceptives, Depo-Provera, abstinence).
• •Each patient must provide written informed consent after full explanation of study protocol, and authorized legal guardian must understand the nature of the study and must also give assent to study participation.
• •Patients must have a baseline (day 0) BPRS score of at least 35 or over 2 of 5 SANS global rating item scores of at least 3.
• •Patients have been receiving clozapine treatment for more than 1 year and there has been no change in clozapine dosage for more than 3 months.
• •Patients must have a history of antipsychotic treatment with at least 2 different kinds prior to clozapine administration.
• •Subjects who are fluent in Korean.