Lead Sponsor

Genzyme, a Sanofi Company

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•life expectancy of at least 12 months,
•patients have received hemodialysis three times per week for 3 months or longer,
•patients maintained on sevelamer in a daily dose of ≤ 9,600 mg as their only phosphate binder with serum phosphorus concentrations at the last two measurements between 3.0 and 6.5 mg/dL (0.97 and 2.10 mmol/L).

•active bowel obstruction,
•dysphagia,
•swallowing disorders,
•severe gastrointestinal motility disorders,
•active ethanol or drug abuse (excluding tobacco),
•need for antidysrhythmic or antiseizure medications used to control these conditions,
•poorly controlled diabetes mellitus or hypertension,
•active vasculitis,
•active malignancy other than basal-cell carcinoma,
•HIV infection,
•any clinically significant unstable medical condition as judged by the investigator.