Phase I Study of Vaccination Schedule of Experimental HIV Vaccines

Exclusion Criteria

• •A volunteer will be excluded if one or more of the following conditions apply:
• •Women:
• •1. Woman who is breast-feeding or planning to become pregnant during the 42 weeks of study participation.
• •Volunteer has received any of the following substances:
• •2. HIV vaccine in a prior clinical trial.
• •3. Immunosuppressive medications or cytotoxic medications or inhaled corticosteroids within the past 3 months (with the exception of corticosteroid nasal spray for allergic rhinitis; topical corticosteroids for an acute uncomplicated dermatitis, short-acting beta-agonists in controlled asthmatics; or a course of corticosteroids that was 10 days or fewer in duration that was completed at least 2 weeks prior to study enrollment for a non-chronic condition).
• •4. Blood products within 120 days prior to HIV screening.
• •5. Immunoglobulin within 60 days prior to HIV screening.
• •6. Investigational research agents within 30 days prior to initial study vaccine administration.
• •7. Live attenuated vaccines within 30 days prior to initial study vaccine administration.
• •8. Medically indicated subunit or killed vaccines, e.g. influenza, pneumococcal, or allergy treatment with antigen injections, within 14 days of study vaccine administration.
• •9. Current anti-tuberculosis prophylaxis or therapy.
• •Volunteer has a history of any of the following clinically significant conditions:
• •10. Serious adverse reactions to vaccines such as anaphylaxis, hives, respiratory difficulty, angioedema, or abdominal pain.
• •11. Autoimmune disease or immunodeficiency
• •12. Asthma that is unstable or required emergent care, urgent care, hospitalization or intubation during the past two years or that requires the use of oral or intravenous corticosteroids.
• •13. Diabetes mellitus (type I or II), with the exception of gestational diabetes.
• •14. History of thyroidectomy or thyroid disease that required medication within the past 12 months.
• •15. Serious angioedema episodes within the previous 3 years or requiring medication in the previous two years.
• •16. Hypertension that is not well controlled by medication or is more than 145/95 at enrollment.
• •17. Bleeding disorder diagnosed by a doctor (e.g. factor deficiency, coagulopathy, or platelet disorder requiring special precautions) or significant bruising or bleeding difficulties with IM injections or blood draws.
• •18. Syphilis infection that is active or a positive serology due to a syphilis infection treated less than six months ago.
• •19. Malignancy that is active or treated malignancy for which there is not reasonable assurance of sustained cure or malignancy that is likely to recur during the period of the study.
• •20. Seizure disorder other than: 1) febrile seizures under the age of two, 2) seizures secondary to alcohol withdrawal more than 3 years ago, or 3) a singular seizure not requiring treatment within the last 3 years.
• •21. Asplenia, functional asplenia or any condition resulting in the absence or removal of the spleen.
• •22. Psychiatric condition that precludes compliance with the protocol; past or present psychoses; past or present bipolar disorder; disorder requiring lithium; or within five years prior to enrollment, history of a suicide plan or attempt.
• •23. Any medical, psychiatric, social condition, occupational reason or other responsibility that, in the judgment of the investigator, is a contraindication to protocol participation or impairs a volunteer's ability to give informed consent.
• •24. A subject with 3 or more of the 5 health risk factors noted below will be excluded:
• •* Current smoker (or quit smoking less than 28 days prior to enrollment)
• •* BMI greater than 35
• •* Fasting low density lipoprotein (LDL) greater than 159 mg/dL or fasting cholesterol greater than 239 mg/dL
• •* Systolic blood pressure greater than 140 mm Hg or diastolic blood pressure greater than 90 mm Hg
• •* Fasting blood glucose greater than 125 mg/dL
• •Note: The fasting blood tests require 8 hours fast prior to the blood draw. The results used for eligibility screening must be from tests completed no more than 12 weeks (84 days) prior to day of enrollment. The individual criteria for BMI (inclusion item 10) and blood pressure (exclusion item 16) must also be met.