Saccadic Eye Movements in Patients With Niemann-Pick Type C Disease

Exclusion Criteria

• •Patients younger than 18 who are unable to give informed assent and/or whose legal guardian is unable to provide informed consent.
• •Patients aged 18 and over who cannot provide informed consent and/or whose legal guardian is unable to provide witnessed informed consent.
• •Fertile patients who do not agree to use adequate contraception throughout the study and for three months after cessation of OGT 918 treatment.
• •Patients who cannot tolerate the study procedures or who are unable to travel to the study center as required by this protocol.
• •Patients currently undergoing therapy with other investigational agents or patients taking drugs or food supplements which may interfere with gastrointestinal absorption or motility.
• •Patients suffering from clinically significant diarrhoea (greater than 3 liquid stools per day for greater than 7 days) without definable cause within 3 months of Screening Visit, or who have a history of significant gastrointestinal disorders.
• •Patients with an intercurrent medical condition that would render them unsuitable for the study e.g. HIV, hepatitis infection.
• •Patients who in the opinion of the investigator (for whatever reason) are thought to be unsuitable for the study.